In addition to being powerful antioxidants, these compounds offer specific vascular support mechanisms that are associated with enhanced endothelial function. Research indicates that CranLoad™ provides statistically significant support for healthy flow-mediated dilation (FMD), an effect similar to arginine administration.
In one study, the peak increase in brachial artery diameter following CranLoad™ supplementation was 2.8% at 60 minutes. A similar physiological effect has been demonstrated with arginine. Citrulline is included to support nitric oxide production in the blood vessel endothelium and other tissues. Research indicates that Citrulline increases plasma arginine in a dose dependent manner and to a greater degree than arginine supplementation.